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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HIRA All Species: 22.42
Human Site: S872 Identified Species: 30.83
UniProt: P54198 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54198 NP_003316.3 1017 111835 S872 A Q C A D F R S S L P S Q D A
Chimpanzee Pan troglodytes XP_001165585 1017 111787 S872 A Q C A D F R S S L P S Q D A
Rhesus Macaque Macaca mulatta XP_001112873 1138 124408 S993 A Q C A D F R S S L P S Q D A
Dog Lupus familis XP_543550 1017 111618 S872 A Q C A D F R S S L P P Q D A
Cat Felis silvestris
Mouse Mus musculus Q61666 1015 111748 N870 A Q C A D F R N S L P S Q D A
Rat Rattus norvegicus NP_001129232 1015 111665 N870 A Q C A D F R N S L P S Q D A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P79987 1019 112055 S878 A Q C A D F R S S L P S Q E A
Frog Xenopus laevis Q8QFR2 1013 112021 S868 A Q C A D Y R S C M P S Q D A
Zebra Danio Brachydanio rerio XP_696478 1010 111223 N865 V Q C A D F R N C L S S Q D V
Tiger Blowfish Takifugu rubipres O42611 1025 111838 N880 V Q C A D F R N C L P N Q D A
Fruit Fly Dros. melanogaster O17468 1047 113397 Q890 A T P A P P Q Q K T A S S A G
Honey Bee Apis mellifera XP_001122939 838 91355 G711 P L S S L Q E G L F R T A G N
Nematode Worm Caenorhab. elegans Q09589 935 103412 N808 S C S N G T T N S A G P L V R
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays Q32SG6 964 105548 Q837 T R A H L E N Q L A S S L A L
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LXN4 1051 115544 A893 L A Y V R F L A R E A D E S R
Baker's Yeast Sacchar. cerevisiae P32479 840 93871 S713 V I I C A I G S K D C K C W C
Red Bread Mold Neurospora crassa Q7RZI0 1035 112420 G871 G E T N V S A G I I P Y L E R
Conservation
Percent
Protein Identity: 100 99.9 88.4 96.5 N.A. 95.7 95.5 N.A. N.A. 86 78 69.8 67.7 31.1 40 26.5 N.A.
Protein Similarity: 100 99.9 88.9 98 N.A. 97.5 97.7 N.A. N.A. 93.1 88.5 83.2 81.3 48 55.1 46.1 N.A.
P-Site Identity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. N.A. 93.3 80 66.6 73.3 20 0 6.6 N.A.
P-Site Similarity: 100 100 100 93.3 N.A. 100 100 N.A. N.A. 100 93.3 73.3 86.6 26.6 13.3 20 N.A.
Percent
Protein Identity: N.A. 25.6 N.A. 25 22.4 25.9
Protein Similarity: N.A. 43.7 N.A. 43.3 41.2 45.8
P-Site Identity: N.A. 6.6 N.A. 6.6 6.6 6.6
P-Site Similarity: N.A. 13.3 N.A. 20 6.6 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 53 6 6 65 6 0 6 6 0 12 12 0 6 12 53 % A
% Cys: 0 6 59 6 0 0 0 0 18 0 6 0 6 0 6 % C
% Asp: 0 0 0 0 59 0 0 0 0 6 0 6 0 53 0 % D
% Glu: 0 6 0 0 0 6 6 0 0 6 0 0 6 12 0 % E
% Phe: 0 0 0 0 0 59 0 0 0 6 0 0 0 0 0 % F
% Gly: 6 0 0 0 6 0 6 12 0 0 6 0 0 6 6 % G
% His: 0 0 0 6 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 6 6 0 0 6 0 0 6 6 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 12 0 0 6 0 0 0 % K
% Leu: 6 6 0 0 12 0 6 0 12 53 0 0 18 0 6 % L
% Met: 0 0 0 0 0 0 0 0 0 6 0 0 0 0 0 % M
% Asn: 0 0 0 12 0 0 6 30 0 0 0 6 0 0 6 % N
% Pro: 6 0 6 0 6 6 0 0 0 0 59 12 0 0 0 % P
% Gln: 0 59 0 0 0 6 6 12 0 0 0 0 59 0 0 % Q
% Arg: 0 6 0 0 6 0 59 0 6 0 6 0 0 0 18 % R
% Ser: 6 0 12 6 0 6 0 42 48 0 12 59 6 6 0 % S
% Thr: 6 6 6 0 0 6 6 0 0 6 0 6 0 0 0 % T
% Val: 18 0 0 6 6 0 0 0 0 0 0 0 0 6 6 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 6 0 % W
% Tyr: 0 0 6 0 0 6 0 0 0 0 0 6 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _